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Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Chemical, mechanical and biological considerations

Paper ID Volume ID Publish Year Pages File Format Full-Text
1655 88 2010 11 PDF Available
Title
Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Chemical, mechanical and biological considerations
Abstract

A poly(propylene glycol-co-lactide) dimethacrylate adhesive with monocalcium phosphate monohydrate (MCPM)/β-tricalcium phosphate (β-TCP) fillers in various levels has been investigated. Water sorption by the photo-polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP). Polymer modulus was found to be enhanced upon raising total calcium phosphate content. With greater DCP levels, faster release of phosphate and calcium ions and improved buffering of polymer degradation products were observed. This could reduce the likelihood of pH-catalyzed bulk degradation and localized acid production and thereby may prevent adverse biological responses. Bone-like MG-63 cells were found to attach, spread and have normal morphology on both the polymer and composite surfaces. Moreover, composites implanted into chick embryo femurs became closely apposed to the host tissue and did not appear to induce adverse immunological reaction. The above results suggest that the new composite materials hold promise as clinical effective bone adhesives.

Keywords
Poly(propylene glycol-co-lactide) dimethacrylate; Calcium phosphate; Mechanical properties; Biocompatibility; Bone repair
First Page Preview
Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: Chemical, mechanical and biological considerations
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 3, March 2010, Pages 845–855
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering