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Optimization of Fc-mediated effector functions of monoclonal antibodies

Paper ID Volume ID Publish Year Pages File Format Full-Text
16556 42508 2009 7 PDF Available
Title
Optimization of Fc-mediated effector functions of monoclonal antibodies
Abstract

The engineering of therapeutic and clinical candidate monoclonal antibodies and Fc fusion proteins is becoming more sophisticated at generating molecules that are better suited to the pharmacological activity required of them. There are at least 14 marketed and clinical candidate antibodies and Fc fusion proteins in which the Fc has been modified, either via changes in amino acid sequence or in glycoforms. Recent research and development activities in Fc engineering to generate ‘fit-for-purpose’ antibodies and Fc fusion proteins are reviewed.

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Optimization of Fc-mediated effector functions of monoclonal antibodies
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 20, Issue 6, December 2009, Pages 685–691
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
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