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Clinical hurdles for the transplantation of cardiomyocytes derived from human embryonic stem cells: role of molecular imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
16591 42511 2007 8 PDF Available
Title
Clinical hurdles for the transplantation of cardiomyocytes derived from human embryonic stem cells: role of molecular imaging
Abstract

Over the past few years, human embryonic stem cells (hESCs) have gained popularity as a potentially ideal cell candidate for tissue regeneration. In particular, hESCs are capable of cardiac lineage-specific differentiation and confer improvement of cardiac function following transplantation into animal models. Although such data are encouraging, there remain significant hurdles before safe and successful translation of hESC-based treatment into clinical therapy, including the ability to assess cells following transplant. To this end, molecular imaging has proven a reliable methodology for tracking the long-term fate of transplanted cells. Imaging reporter genes that are introduced into the cells before transplantation enable non-invasive and longitudinal studies of cell viability, location and behaviour in vivo. Therefore, molecular imaging is expected to play an increasing role in characterizing the biology and physiology of hESC-derived cardiac cells in living subjects.

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Clinical hurdles for the transplantation of cardiomyocytes derived from human embryonic stem cells: role of molecular imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 18, Issue 1, February 2007, Pages 38–45
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
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