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Preparation, characterization and in vitro efficacy of an acid-modified β-TCP material for dental hard-tissue remineralization

Paper ID Volume ID Publish Year Pages File Format Full-Text
1669 88 2010 10 PDF Available
Title
Preparation, characterization and in vitro efficacy of an acid-modified β-TCP material for dental hard-tissue remineralization
Abstract

A blended material composed of beta-tricalcium phosphate (β-TCP) and fumaric acid (FA) was prepared using a mechanochemical process. The structure and properties of the TCP–FA material was probed using particle size analysis, infrared, 31P and 13C solid-state nuclear magnetic resonance (NMR) spectroscopy, powder X-ray diffraction and calcium bioavailability. NMR studies showed that orthophosphate environments within β-TCP remain largely unaffected in the presence of FA during mechanochemical processing; alternately, 13C data indicated the carboxylic groups of FA are strongly affected during processing with β-TCP. X-ray results reveal β-TCP diffraction plane shifting with lattice contractions likely arising at the C3 symmetry site. While milled β-TCP (mTCP) produces a higher flux of bioavailable calcium relative to native β-TCP, the mechanochemical conditioning of TCP–FA generates more than seven times the level of ionic calcium relative to mTCP. Collectively, the results from these studies indicate FA interfaces with calcium oxide polyhedra of the β-TCP hexagonal crystal lattice, especially with the underbonded CaO3 cluster manifested within the C3 symmetry site of the β-TCP motif. An in vitro remineralization/demineralization pH cycling dental model was then used to assess the potential of the TCP–FA material in reversing early stage non-cavitated enamel lesions. Characterization of the remineralization via surface and longitudinal microhardness measurements demonstrated that the TCP–FA material provides statistically superior remineralization relative to milled and native β-TCP.

Keywords
β-TCP; Fumaric acid; Dental; Enamel; Mechanochemical
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Preparation, characterization and in vitro efficacy of an acid-modified β-TCP material for dental hard-tissue remineralization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 3, March 2010, Pages 969–978
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us