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Mammalian cell factories for efficient and stable protein expression

Paper ID Volume ID Publish Year Pages File Format Full-Text
16728 42535 2006 6 PDF Available
Title
Mammalian cell factories for efficient and stable protein expression
Abstract

As the commercial market for therapeutic protein production from mammalian cells has expanded, so has the requirement for improved efficiency and stability of production. Rapid developments have been made in understanding the molecular environment of transgenes in chromatin, including elucidation of the contribution of epigenetic modifications to expression, and this understanding is being used to enhance expression from host cells. Technical advances surrounding the ‘omics’ revolution are enabling the rational identification of complex control factors that define the flow of information from transgene to desired protein. Using information from ‘omics’ interrogations, directed cell engineering has been employed to enhance the translational and secretory capacity of host cells. Taken together, these recent advances are likely to lead to improved routes for protein production in the future.

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Mammalian cell factories for efficient and stable protein expression
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 17, Issue 4, August 2006, Pages 381–386
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us