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Advances in ovarian cancer diagnosis: A journey from immunoassays to immunosensors

Paper ID Volume ID Publish Year Pages File Format Full-Text
16779 42612 2016 16 PDF Available
Title
Advances in ovarian cancer diagnosis: A journey from immunoassays to immunosensors
Abstract

•Overview of ovarian cancer biomarkers and their role in diagnosis and prognosis.•Critical assessesment current methods for detection of ovarian cancer.•Evaluation of sensitivity and detection range of immunoassays and immunosensors for ovarian cancer diagnosis.•Comparison of performance characteristics of immunosensors, with and without mediators, and label-free detection.•Discussion of characteristics and limitations associated with commercialised technologies.

This review focuses on the technological advancements, challenges and trends in immunoassay technologies for ovarian cancer diagnosis. Emphasis is placed on the principles of the technologies, their merits and limitations and on the evolution from laboratory-based methods to point-of-care devices. While the current market is predominantly associated with clinical immunoassay kits, over the last decade a major thrust in development of immunosensors is evident due to their potential in point-of-care devices. Technological advancements in immunosensors, extending from labeled to label-free detection, with and without mediators, for enhancing proficiencies and reliability have been dealt with in detail. Aspects of the utilisation of nanomaterials and immobilization strategies for enhancing sensitivity and altering the detection range have also been addressed. Finally, we have discussed some distinct characteristics and limitations associated with the recently commericalised technologies used for quantitation of relevant ovarian cancer markers.

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Keywords
Ovarian carcinoma; Biomarker; Immunoassay; Immunosensor; Nanomaterial
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 89, July 2016, Pages 15–30
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us