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Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
1681 88 2010 10 PDF Available
Title
Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications
Abstract

This study reports on the performance of electrospun hyperbranched polyglycerol nanofibers capable of providing an active agent delivery for wound dressing applications. The aim of this work was to prepare electrospun HPGL nanofibers containing Calendula officinalis as a wound-healing and anti-inflammatory agent. The morphology of the electrospun HPGL–C. officinalis nanofibers was analyzed using a scanning electron microscope. The results showed that the diameters of the fibers were in nanoscales. The release of C. officinalis from the electrospun HPGL fibers was determined by HPLC at a physiological temperature (37 °C). Rapid release of the C. officinalis from the electrospun HPGL–C. officinalis nanofibers was exhibited as result of the high swelling ability as well as the high porosity of the electrospun HPGL–C. officinalis membranes. The degree of swelling, and the mechanical and biocompatible properties of the electrospun HPGL fibers were determined. The results showed that, in physiological conditions, the water absorption into the HPGL electrospun fibers slowed down, governed by the rate at which the electrospun HPGL–C. officinalis membranes interacted with the physiological fluid. The rate of release of C. officinalis seemed to depend on the C. officinalis content in the HPGL nanofibers. From the elastic modulus, it could be seen that elastic electrospun HPGL fibers were obtained with increments of C. officinalis content in the HPGL–C. officinalis membranes. The results of in vivo experiments in rats suggested that HPGL–C. officinalis might be an interesting bioactive wound dressing material for clinical applications.

Keywords
Hyperbranched polyglycerol; Calendula officinalis; Hydrogel; Electrospun nanofibers; Wound healing
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Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 3, March 2010, Pages 1069–1078
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us