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Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone)

Paper ID Volume ID Publish Year Pages File Format Full-Text
1682 88 2010 11 PDF Available
Title
Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone)
Abstract

Star block copolymers based on poly[(R)-3-hydroxybutyrate] (PHB) and poly(ε-caprolactone) (PCL), termed SPHBCL, were successfully synthesized with structural variation on arm numbers and lengths via coupling reactions and ring opening polymerizations. Arm numbers 3, 4 and 6 of SPHBCL were synthesized by using different multifunctional cores, such as trimethyol propane, pentaerythiritol and dipentaerthritol, respectively. Gel permeation chromatography (GPC) and 1H and 13C nuclear magnetic resonance were used to characterize the structure of SPHBCL. GPC failed to produce accurate molecular weights of the SPHBCL due to the discrepancy of star copolymer structures. The melting temperature of SPHBCL decreased with increasing degree of branching. Thermal decomposition temperature was revealed to be lower than that of linear block copolymer LPHBCL counterparts based on PHB and PCL. Films made from various SPHBCL copolymers had different porous or networking surface morphology, and all possessed improved biocompatibility in terms of less blood clotting and more osteoblast cell growth compared with their corresponding homopolymers PHB and PCL. Among them, it was found, however, that the 4-arm star block copolymer 4SPHBCL-25 showed unique surface properties, i.e. a regular nanoravine structure was observed by scanning electron microscopy and atomic force microscopy. This 4-arm star copolymer also showed the best biocompatibility.

Keywords
Polyhydroxybutyrate (PHB); Poly(ε-caprolactone) (PCL); Star polymers; Biodegradation; Biocompatibility
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Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 3, March 2010, Pages 1079–1089
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us