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Synthesis and characterization of thermoresponsive polyamidoamine–polyethylene glycol–poly(d,l-lactide) core–shell nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
1688 88 2010 9 PDF Available
Title
Synthesis and characterization of thermoresponsive polyamidoamine–polyethylene glycol–poly(d,l-lactide) core–shell nanoparticles
Abstract

This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine–polyethylene glycol–poly(d,l-lactide) (PAMAM–PEG–PDLLA) core–shell nanoparticles. A series of dendritic PEG–PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol−1) to polyamidoamine (PAMAM) dendrimer G3.0 and subsequent ring-opening polymerization of DLLA. The ninhydrin assay, 1H NMR, Fourier transform infrared spectroscopy, dynamic light scattering and atomic force microscopy were used to characterize the structure and compositions of dendritic PEG–PDLLA nanoparticles. The sol–gel phase transition of aqueous dendritic PEG–PDLLA solutions was measured using UV–visual spectroscopy. According to our results dendritic PEG–PDLLA nanoparticles in aqueous solution can self-assemble into sub-micron/micron aggregates, the size of which is dependent on temperature and PEG–PDLLA chain length. Further, dendritic PEG–PDLLA solutions exhibit a sol–gel phase transition with increasing temperature. The constructed dendritic PEG–PDLLA nanoparticles possessed high cytocompatibility, which was significantly improved compared with PAMAM dendrimers. The potential of dendritic PEG–PDLLA nanoparticles for encapsulation of water-insoluble drugs such as camptothecin was demonstrated. The dendritic PEG–PDLLA nanoparticles we developed offer greater structural flexibility and provide a novel nanostructured thermoresponsive carrier for drug delivery.

Keywords
Dendrimers; Drug delivery; Nanomedicine; PEG–PLA co-polymers; Sol–gel phase transition
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Synthesis and characterization of thermoresponsive polyamidoamine–polyethylene glycol–poly(d,l-lactide) core–shell nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 3, March 2010, Pages 1131–1139
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us