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Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method

Paper ID Volume ID Publish Year Pages File Format Full-Text
1692 88 2010 11 PDF Available
Title
Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method
Abstract

Porous gelatin scaffolds with microtubule orientation structure were manufactured by unidirectional freeze-drying technology, and their porous structure was characterized by scanning electron microscopy. Scaffolds with tunable pore size and high porosity up to 98% were obtained by adjusting the concentration of the gelatin solution and crosslinking agent during the preparation process. All the porous gelatin scaffolds exhibited oriented microtubule pores, with width and length from 50 to 100 μm and 100 to 500 μm, respectively. Meanwhile, the properties of the scaffolds, such as porosity, water adsorption ability and compressive strength, were studied. In vitro enzymatic degradation results showed that the absolute weight loss of the gelatin scaffolds exhibited an increasing trend from low to high gelatin concentration used to prepare gelatin scaffolds; in vitro cell culture results indicated that the porous gelatin scaffolds were non-toxic to cartilage cells, since the cells spread and grew well.

Keywords
Unidirectional freeze-drying; Gelatin; Scaffolds; Tissue engineering
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Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 3, March 2010, Pages 1167–1177
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us