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Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration

Paper ID Volume ID Publish Year Pages File Format Full-Text
1718 89 2010 8 PDF Available
Title
Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration
Abstract

The effect of polymer infiltration on the compressive strength of β-tricalcium phosphate (TCP) scaffolds fabricated by robocasting (direct write assembly) is analyzed in this work. Porous structures consisting of a tetragonal three-dimensional mesh of interpenetrating rods were fabricated from concentrated TCP inks with suitable viscoelastic properties. Biodegradable polymers (polylactic acid (PLA) and poly(ε-caprolactone) (PCL)) were infiltrated into selected scaffolds by immersion of the structure in a polymer melt. Infiltration increased the uniaxial compressive strength of these model scaffolds by a factor of three (PCL) or six (PLA). It also considerably improved the mechanical integrity of the structures after initial cracking, with the infiltrated structure retaining a significant load-bearing capacity after fracture of the ceramic rods. The strength improvement in the infiltrated scaffolds was attributed to two different contributions: the sealing of precursor flaws in the ceramic rod surfaces and the partial transfer of stress to the polymer, as confirmed by finite element analysis. The implications of these results for the mechanical optimization of scaffolds for bone tissue engineering applications are discussed.

Keywords
Robocasting; Scaffolds; Polymer infiltration; β-Tricalcium phosphate; Strength
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Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 11, November 2010, Pages 4361–4368
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us