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Application of a novel type impinging streams reactor in solid–liquid enzyme reactions and modeling of residence time distribution using GDB model

Paper ID Volume ID Publish Year Pages File Format Full-Text
17225 42653 2014 7 PDF Available
Title
Application of a novel type impinging streams reactor in solid–liquid enzyme reactions and modeling of residence time distribution using GDB model
Abstract

•Using a reactor with a combination of plug flow and impinging streams system.•Obtaining 30% conversion of glucose within a short residence time (9 s).•Obtaining equilibrium conversion (50%) within 20 s.•Modeling of RTD using GDB model.

Solid–liquid enzyme reactions constitute important processes in biochemical industries. The isomerization of d-glucose to d-fructose, using the immobilized glucose isomerase (Sweetzyme T), as a typical example of solid–liquid catalyzed reactions has been carried out in one stage and multi-stage novel type of impinging streams reactors. Response surface methodology was applied to determine the effects of certain pertinent parameters of the process namely axial velocity (A), feed concentration (B), nozzles’ flow rates (C) and enzyme loading (D) on the performance of the apparatus. The results obtained from the conversion of glucose in this reactor were much higher than those expected in conventional reactors, while residence time was decreased dramatically. Residence time distribution (RTD) in a one-stage impinging streams reactor was investigated using colored solution as the tracer. The results showed that the flow pattern in the reactor was close to that in a continuous stirred tank reactor (CSTR). Based on the analysis of flow region in the reactor, gamma distribution model with bypass (GDB) was applied to study the RTD of the reactor. The results indicated that RTD in the impinging streams reactor could be described by the latter model.

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Keywords
Enzymatic reactions; Glucose isomerase; Impinging streams reactor; Residence time distribution; Mixing model
First Page Preview
Application of a novel type impinging streams reactor in solid–liquid enzyme reactions and modeling of residence time distribution using GDB model
Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 55, 5 February 2014, Pages 14–20
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering