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Using recombinant DNA technology for the development of live-attenuated dengue vaccines

Paper ID Volume ID Publish Year Pages File Format Full-Text
17247 42654 2012 6 PDF Available
Title
Using recombinant DNA technology for the development of live-attenuated dengue vaccines
Abstract

Dramatic increases in dengue (DEN) incidence and disease severity have been reported, in great part due to the geographic expansion of Aedes aegypti and Aedes albopictus mosquitoes. One result is the expanded co-circulation of all dengue 1-4 serotype viruses (DENV) in urban areas worldwide, especially in South and South-East Asia, and South America. DEN disease severity ranges from asymptomatic infections to febrile dengue fevers (DF) to life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). There is an urgent need for a safe and effective tetravalent DEN vaccine. Several live attenuated, tetravalent DEN vaccine candidates have been generated by recombinant DNA technology; these candidates are capable of providing immunity to all four DENV serotypes. In this paper we review (a) recombinant live-attenuated DEN vaccine candidates in terms of deletion, antigen chimerization, and the introduction of adaptive mutations; (b) strategies for improving tetravalent vaccine attenuation; and (c) live-attenuated DENV vaccine development.

► Tetravalent dengue vaccines are urgently needed. ► Recombinant DNA technology is used for antigen chimerization. ► Recombinant DNA technology is used for antigen deletion and adaptive mutation.

Keywords
Live-attenuated Dengue vaccines; Recombinant DNA technology; Antigen chimerization; Adaptive mutations
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Using recombinant DNA technology for the development of live-attenuated dengue vaccines
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 51, Issue 2, 15 July 2012, Pages 67–72
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us