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Laccase-poly(lactic-co-glycolic acid) (PLGA) nanofiber: Highly stable, reusable, and efficacious for the transformation of diclofenac

Paper ID Volume ID Publish Year Pages File Format Full-Text
17254 42654 2012 6 PDF Available
Title
Laccase-poly(lactic-co-glycolic acid) (PLGA) nanofiber: Highly stable, reusable, and efficacious for the transformation of diclofenac
Abstract

Nanobiocatalysis has received growing attention for use in commercial applications. We investigated the efficiency, stability, and reusability of laccase-poly(lactic-co-glycolic acid) (PLGA) nanofiber for diclofenac transformation. NH stretching vibrations (3400–3500 cm−1 and 1560 cm−1) in FT-IR spectra confirmed immobilization of laccase on PLGA nanofibers. The relative activity of immobilized laccase was 82% that of free laccase. Immobilized laccase had better storage, pH, and thermal stability than free laccase. The immobilized laccase produced complete diclofenac transformation in three reuse cycles, which was extended to 6 cycles in the presence of syringaldehyde. Results suggest that laccase-PLGA nanofiber may be useful for removing diclofenac from aqueous sources and has potential for other commercial applications.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The efficiency, stability, and reusability of laccase-PLGA nanofiber for the transformation of diclofenac was investigated. ► A band appearing at NH stretching vibrations in FT-IR spectra confirmed laccase attachment to the PLGA nanofiber. ► Immobilized laccase had better storage, pH, and thermal stability than free laccase. ► Immobilized laccase showed complete diclofenac transformation up to 3 recycles, which could be extended to 6 recycles in the presence of syringaldehyde.

Keywords
Diclofenac; Laccase; Nanofiber; Stability; Transformation
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Laccase-poly(lactic-co-glycolic acid) (PLGA) nanofiber: Highly stable, reusable, and efficacious for the transformation of diclofenac
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 51, Issue 2, 15 July 2012, Pages 113–118
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us