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In vitro study of hydroxyapatite-based photocurable polymer composites prepared by laser stereolithography and supercritical fluid extraction

Paper ID Volume ID Publish Year Pages File Format Full-Text
1732 90 2008 8 PDF Available
Title
In vitro study of hydroxyapatite-based photocurable polymer composites prepared by laser stereolithography and supercritical fluid extraction
Abstract

The fabrication of three-dimensional (3-D) structures using computer-controlled ultraviolet (UV) photopolymerization of acrylates (laser stereolithography) often results in the trapping of residual unreacted monomer and initiator. These residuals can leach from the finished structure and affect the biological response of cells and tissues. Thus the potential applications of these structures for tissue engineering have not been fully realized. In this paper we demonstrate that conventional post-lithography treatments followed by processing in the environmentally benign solvent, supercritical carbon dioxide (scCO2), dramatically increased biocompatibility. The scCO2 processing of pure polyacrylate and polyacrylate/hydroxyapatite composite structures extracts residuals from all structures including those that had received full conventional post-lithography treatment (acetone washing/UV drying). Human osteoblast cells seeded on the extracted surfaces of these structures demonstrated increased cell attachment and proliferation on the scCO2-treated materials.

Keywords
Hydroxyapatite; Supercritical CO2; Laser stereolithography; Biocompatibility; Osteoblast
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In vitro study of hydroxyapatite-based photocurable polymer composites prepared by laser stereolithography and supercritical fluid extraction
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 6, November 2008, Pages 1603–1610
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us