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Post-self-assembly experimentation on extruded collagen fibres for tissue engineering applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
1737 90 2008 11 PDF Available
Title
Post-self-assembly experimentation on extruded collagen fibres for tissue engineering applications
Abstract

Extruded collagen fibres have been shown to constitute a biomimetic three-dimensional scaffold with numerous tissue engineering applications. The multi-step fabrication process of this material provides opportunities for further advancements to improve the properties of the final product. Herein we investigated the influence of the post-self-assembly washing baths on the structural, mechanical and thermal properties of these fibres. The surface morphology and the inter-fibre packing were similar for every treatment. The overnight incubation in isopropanol yielded fibres with the highest temperature and energy of denaturation (p < 0.013). Typical s- and j-shape stress–strain curves were obtained for all treatments in the dry and wet state respectively. Rehydration of the fibres resulted in increased fibre diameter (p < 0.006) and reduced stress (p < 0.001), force (p < 0.001) and modulus (p < 0.002) values for every treatment. In the dry state, the alcohol-treated fibres were characterized by the highest stress (p < 0.002) values; whilst in the wet state the Tris–HCl-treated fibres were the weakest (p < 0.006). For every treatment, in both dry and wet state, a strong and inverse relationship between the fibre diameter and the stress at break was observed. Overall, the fibres produced were characterized by properties similar to those of native tissues.

Keywords
Extruded collagen fibres; Post-self-assembly; Mechanical properties; Thermal properties; Structural characteristics
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 6, November 2008, Pages 1646–1656
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us