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The betulinic acid production from betulin through biotransformation by fungi

Paper ID Volume ID Publish Year Pages File Format Full-Text
17442 42669 2009 6 PDF Available
Title
The betulinic acid production from betulin through biotransformation by fungi
Abstract

Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important physiological and pharmacological properties. In order to obtain betulinic acid, betulin was submitted to transformation with the selected microorganisms. Betulin biotransformation was carried out with the filamentous fungi Armillaria luteo-virens Sacc QH (ALVS), Aspergillus foetidus ZU-G1 (AF) and Aspergillus oryzae (AO) under seven kinds of transformation condition. As a result of transformation of betulin, A. luteo-virens Sacc QH was the best biocatalyst to produce betulinic acid under the designed conditions. Transformation caused by pre-cultured fungal mycelia, a process designated as G2, was favorable condition for betulin biotransformation as the productivity of betulinic acid was evaluated (>20%). M1 and M2 systems, where the betulin substrate was micro-emulsified in mixtures of Tween 80 and organic solvents, were potential substitutes for G2. The possible pathway of betulin transformation is postulated in this work. The use of fungi and transformation mode described in current work are viable procedures for producing betulinic acid, which is of most importance to replace chemical synthesis ways.

Keywords
Betulinic acid; Betulin; Biotransformation; Screening and identification; Armillaria luteo-virens Sacc QH
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 45, Issue 3, 7 September 2009, Pages 175–180
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us