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Biostability and biocompatibility of poly(ester urethane)–gold nanocomposites

Paper ID Volume ID Publish Year Pages File Format Full-Text
1753 90 2008 12 PDF Available
Title
Biostability and biocompatibility of poly(ester urethane)–gold nanocomposites
Abstract

Nanocomposites from a polyester-type water-borne polyurethane (PU) containing different amounts (17.4–174 ppm) of gold (Au) nanoparticles (∼5 nm) were prepared. A previous study has shown that the Au nanoparticles could induce surface morphological transformations in the PU (e.g. the mesophase transition from hard lamellae to soft micelles), which modify the physicochemical properties of the PU as well as the fibroblast response to the PU. The current study focused on the biostability and biocompatibility of the nanocomposites. The nanocomposites were characterized by transmission electron microscopy and X-ray photoelectron spectroscopy, and their oxidative stability and free radical scavenging ability were tested. The inflammatory response was evaluated by monocyte activation in vitro and rat subcutaneous implantation in vivo. It was found that the nanocomposites containing 43.5–65 ppm of Au had the least monocyte activation and tissue reactions. PU and the nanocomposites were rather resistant to oxidative degradation in vitro and biodegradation in vivo. The nanocomposites exhibited greater free radical scavenging abilities than the original PU. Based on the above results, the significantly enhanced biocompatibility of the PU–Au nanocomposites with 43.5–65 ppm of gold over the original PU appeared to be a result of the extensively modified surface morphology and greater free radical scavenging ability, instead of due to the difference in biostability.

Keywords
Polyurethane; Nanocomposite; Biocompatibility; Gold nanoparticles; Biostability
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Biostability and biocompatibility of poly(ester urethane)–gold nanocomposites
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 6, November 2008, Pages 1797–1808
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us