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Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
1777 90 2008 8 PDF Available
Title
Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats ☆
Abstract

In the present work we synthesized inorganic oxide nanoparticle carriers of platinum compounds and tested their therapeutic effect on animal models in which C6 glioma cells have been inoculated. TiO2-containing Pt(NH3)4Cl2 complexes were synthesized using sol–gel methods. The platinum species are chemically bonded to the TiO2 carrier, as shown by Fourier transform infrared spectroscopy of probe molecules. Treatment with TiO2–Pt nanoparticles reduces tumour growth rate by up to 56%, showing that a synergistic effect exists between the TiO2 carrier and the platinum drug.

Keywords
Nanotherapy; Cancer; Platinum; TiO2; Nanoparticles
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Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 6, November 2008, Pages 2037–2044
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us