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Enzymatic syntheses of dopamine glycosides

Paper ID Volume ID Publish Year Pages File Format Full-Text
17855 42701 2009 7 PDF Available
Enzymatic syntheses of dopamine glycosides

Glucoamylase from Rhizopus mold and β-glucosidase catalysed synthesis of dopamine-d-glucoside was optimized in terms of pH, buffer, enzyme, dopamine concentrations and incubation period in organic media. Under the optimum conditions, β-glucosidase showed regioselectivity by giving rise to 3-hydroxy-4-O-(β-d-glucopyranosyl)phenylethylamine 5b. Presence of hydroxyl group at 3rd and 4th position of phenyl ring showed only monoglycosylation/arylation products with d-glucose 2, d-galactose 3 and d-mannose 4 for both the enzymes. Synthesized glycosides also exhibited ACE inhibition and antioxidant activities.

Enzymatic synthesis; Dopamine glycosides; Glucoamylase; β-Glucosidase; ACE inhibition; Antioxidant activity
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Enzymatic syntheses of dopamine glycosides
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 44, Issue 1, 6 January 2009, Pages 33–39
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Physical Sciences and Engineering Chemical Engineering Bioengineering