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Fed-batch gluconic acid production from Penicillium variabile P16 under different feeding strategies

Paper ID Volume ID Publish Year Pages File Format Full-Text
17886 42703 2008 5 PDF Available
Title
Fed-batch gluconic acid production from Penicillium variabile P16 under different feeding strategies
Abstract

Penicillium variabile P16 is characterized by the ability to release high levels of glucose oxidase when grown in glucose-rich media converting, at the same time, glucose into gluconic acid. This work reports on gluconic acid production by the above strain grown in bench-top reactor under different strategies, traditional batch and fed-batch processes; Na2CO3 was substituted for CaCO3 as the buffering agent in order to prevent calcium gluconate precipitation over the mycelium that would limit oxygen uptake and, as a consequence, glucose conversion. Best results were obtained with an improved fed-batch process which, in addition to glucose, was continuously fed with nitrogen and minerals at a flow rate of 0.02 ml min−1: yield and total productivity were 99.4% and 2.02 g h−1, respectively, and remained constant till the end of the fermentation (240 h).

Keywords
Penicillium variabile; Fermentation; Biotransformation; Gluconic acid; Fed-batch; Feeding strategies
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Fed-batch gluconic acid production from Penicillium variabile P16 under different feeding strategies
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 42, Issue 5, 4 April 2008, Pages 445–449
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us