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A novel strategy of enhanced glutathione production in high cell density cultivation of Candida utilis—Cysteine addition combined with dissolved oxygen controlling

Paper ID Volume ID Publish Year Pages File Format Full-Text
17942 42706 2008 6 PDF Available
Title
A novel strategy of enhanced glutathione production in high cell density cultivation of Candida utilis—Cysteine addition combined with dissolved oxygen controlling
Abstract

Effects of dissolved oxygen (DO) concentration on glutathione (GSH) production and cysteine oxidation were investigated in high cell density cultivation of Candida utilis. Lower DO concentration favors cysteine absorption but retards GSH production. Higher DO promotes GSH production but accelerates cysteine oxidation in the broth. A two-step DO control strategy was developed and compared for the potential in enhancing GSH production and cysteine absorption. By using the two-step DO control strategy, a 40% decrease in cysteine addition and a 13% increase in GSH production are observed as compared with that at constant DO of 40%.

Keywords
Candida utilis; Glutathione (GSH); High cell density cultivation; Cysteine addition; Dissolved oxygen (DO)
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A novel strategy of enhanced glutathione production in high cell density cultivation of Candida utilis—Cysteine addition combined with dissolved oxygen controlling
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 42, Issue 3, 4 February 2008, Pages 284–289
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us