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Enhance of anthraquinone production by effect of proline and aminoindan-2-phosphonic acid in Rubia tinctorum suspension cultures

Paper ID Volume ID Publish Year Pages File Format Full-Text
17986 42708 2007 5 PDF Available
Title
Enhance of anthraquinone production by effect of proline and aminoindan-2-phosphonic acid in Rubia tinctorum suspension cultures
Abstract

Anthraquinones (AQs) are compounds with a wide variety of interesting properties, which could be obtained by Rubia tinctorum suspension cultures. The present paper reports the effect of proline and aminoindan-2-phosphonic acid (AIP) on AQs production. The addition of proline (0.25 mM) or AIP (100 μM) enhance, up to 50% the AQ biosynthesis in R. tinctorum suspension culture. This increase is similar to those obtained by elicitation. Phenylalanine ammonia liase (PAL) activity was higher in presence of proline but no change in phenolic acid contents was found. Glucose-6-phosphate dehydrogenase (G6PDH) activity was not affected in cell cultures treated with proline. Addition of AIP produced PAL inhibition and lower levels of phenolic acid contents. These results show that it is possible to increase the AQs level in R. tinctorum suspension culture by metabolic manipulation and by inhibition of the key enzymes of the metabolic pathways that compete with AQs for a common substrate.

Keywords
Anthraquinones; Rubia tinctorum; Suspension cultures; Proline; Amidoindan-2-phosphonic acid
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Enhance of anthraquinone production by effect of proline and aminoindan-2-phosphonic acid in Rubia tinctorum suspension cultures
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 41, Issues 1–2, 2 July 2007, Pages 181–185
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us