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Microbial transformation of dehydrocostuslactone and costunolide by Mucor polymorphosporus and Aspergillus candidus

Paper ID Volume ID Publish Year Pages File Format Full-Text
18137 42713 2007 7 PDF Available
Title
Microbial transformation of dehydrocostuslactone and costunolide by Mucor polymorphosporus and Aspergillus candidus
Abstract

Twenty strains of filamentous fungi (from nine genera) and four species of bacteria were screened for their capabilities to transform dehydrocostuslactone (1) and costunolide (10). Stereo- and region-specific hydroxylation, epoxidation and hydrogenation reactions of the substrates by Mucor polymorphosporus AS 3.3443 and Aspergillus candidus CICC 2360 were reported. Twelve transformed products were obtained and their structures were identified on the basis of their spectral data. Among them, 10α,14β-epoxy-11α,13-dihydrodehydrocostuslactone and 10α,14-dihydroxy-11α,13-dihydrodehydrocostuslactone are new compounds. The biotransformation kinetics were also investigated.

Keywords
Dehydrocostuslactone; Costunolide; Biotransformation; Mucor polymorphosporus; Aspergillus candidus
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Microbial transformation of dehydrocostuslactone and costunolide by Mucor polymorphosporus and Aspergillus candidus
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 40, Issue 5, 3 April 2007, Pages 1013–1019
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us