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Microbial transformation of the bioactive sesquiterpene, cyclonerodiol, by the ascomycete Penicillium sp. and the actinomycete Streptomyces sp.

Paper ID Volume ID Publish Year Pages File Format Full-Text
18162 42713 2007 5 PDF Available
Title
Microbial transformation of the bioactive sesquiterpene, cyclonerodiol, by the ascomycete Penicillium sp. and the actinomycete Streptomyces sp.
Abstract

Biological transformation of the bioactive sesquiterpene, cyclonerodiol (1), isolated from marine-derived fungus Myrothecium sp., was studied. Preparative-scale fermentation of 1 with marine-derived fungus Penicillium sp. resulted in the isolation of a new glycosidic metabolite, 7-O-(β-d-mannopyranosyl)cyclonerodiol (2). Fermentation of 1 for 2 weeks with a marine isolate of the actinomycete bacteria Streptomyces sp. also afforded two oxidized geometrical isomers, 10(Z)- and 10(E)-cyclonerotriols (3, 4). The stereostructure of the metabolites obtained was assigned on the basis of detailed spectroscopic data analyses and chemical reaction.

Keywords
Biotransformation; Cyclonerodiol; Cyclonerotriol; Cyclonerodiol mannopyranoside; Streptomyces sp.; Penicillium sp
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Microbial transformation of the bioactive sesquiterpene, cyclonerodiol, by the ascomycete Penicillium sp. and the actinomycete Streptomyces sp.
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 40, Issue 5, 3 April 2007, Pages 1188–1192
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us