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Oriented bioactive glass (13-93) scaffolds with controllable pore size by unidirectional freezing of camphene-based suspensions: Microstructure and mechanical response

Paper ID Volume ID Publish Year Pages File Format Full-Text
1824 91 2011 11 PDF Available
Title
Oriented bioactive glass (13-93) scaffolds with controllable pore size by unidirectional freezing of camphene-based suspensions: Microstructure and mechanical response
Abstract

Scaffolds of 13-93 bioactive glass (composition 6.0 Na2O, 7.9 K2O, 7.7 MgO, 22.1 CaO, 1.7 P2O5, 54.6 SiO2 (mol.%)) containing oriented pores of controllable diameter were prepared by unidirectional freezing of camphene-based suspensions (10 vol.% particles) on a cold substrate (−196 °C or 3 °C). By varying the annealing time (0–72 h) to coarsen the camphene phase, constructs with the same porosity (86 ± 1%) but with controllable pore diameters (15–160 μm) were obtained after sublimation of the camphene. The pore diameters had a self-similar distribution that could be fitted by a diffusion-controlled coalescence model. Sintering (1 h at 690 °C) was accompanied by a decrease in porosity and pore diameter, the magnitude of which depended on the pore size of the green constructs, giving scaffolds with a porosity of 20–60% and average pore diameter of 6–120 μm. The compressive stress vs. deformation response of the sintered scaffolds in the orientation direction was linear, followed by failure. The compressive strength and elastic modulus in the orientation direction varied from 180 MPa and 25 GPa (porosity = 20%) to 16 MPa and 4 GPa (porosity = 60%), respectively, which were 2–3 times larger than the values in the direction perpendicular to the orientation. The potential use of these 13-93 bioactive glass scaffolds for the repair of large defects in load-bearing bones, such as segmental defects in long bones, is discussed.

Keywords
Bioactive glass; Scaffolds; Bone repair; Unidirectional freeze casting; Camphene
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Oriented bioactive glass (13-93) scaffolds with controllable pore size by unidirectional freezing of camphene-based suspensions: Microstructure and mechanical response
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 1, January 2011, Pages 406–416
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us