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Investigating the relationship between the specific glucose uptake rate and nisin production in aerobic batch and fed-batch glucostat cultures of Lactococcus lactis

Paper ID Volume ID Publish Year Pages File Format Full-Text
18247 42715 2007 7 PDF Available
Title
Investigating the relationship between the specific glucose uptake rate and nisin production in aerobic batch and fed-batch glucostat cultures of Lactococcus lactis
Abstract

The relationship between specific glucose uptake rate and nisin production by Lactococcus lactis was investigated in aerobic batch and fed-batch cultures in which glucose was maintained stable during the production phase (glucostat) at levels ranging from 2.5 to 75 g/l. Both initial concentration and the level of glucose the cells experience affected specific nisin production rates. The maximum nisin titer obtained in glucostat cultures was 6100 IU/ml at 10 g/l glucose, a significantly higher amount compared to the maximum titer of 3122 IU/ml in batch culture with 25 g/l initial glucose concentration. At glucose concentration levels exceeding 10 g/l in fed-batch culture, specific nisin production rates were reduced and specific glucose uptake rates data showed that glucose transport inside the cells is saturated. Obviously, the concentration of glucose regulates its uptake and improving its uptake could result in nisin yield improvement. By employing the tool of glucostat fed-batch culture, glucose concentration was effectively controlled at levels ensuring an optimum uptake rate for maximum nisin production.

Keywords
Lactococcus lactis; Nisin; Glucose; Fed-batch culture; Glucostat
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Investigating the relationship between the specific glucose uptake rate and nisin production in aerobic batch and fed-batch glucostat cultures of Lactococcus lactis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 40, Issue 6, 2 May 2007, Pages 1557–1563
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us