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Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani

Paper ID Volume ID Publish Year Pages File Format Full-Text
18251 42715 2007 7 PDF Available
Title
Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani
Abstract

Twenty strains of filamentous fungi (from nine genera) and four species of bacteria were screened for their capabilities to transform bufadienolides. The highly stereo- and regiospecific isomerization and dehydrogenation of three major bufadienolides (resibufogenin, cinobufagin and bufalin) at 3-OH by Fusarium solani AS 3.1829 were reported. Three major transformed products were obtained and their structures were identified as 3-epi-resibufogenin (1a), 3-epi-bufalin (2a), 3-keto-cinobufagin (3a), respectively, on the basis of their spectral data. The reaction kinetics and the effects of pH, substrate concentration and incubation phase on the biotransformation were also investigated.

Keywords
Biotransformation; Resibufogenin; Cinobufagin; Bufalin; Fusarium solani
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Highly selective isomerization and dehydrogenation of three major bufadienolides at 3-OH by Fusarium solani
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 40, Issue 6, 2 May 2007, Pages 1585–1591
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us