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Transformation of steroids by Trichoderma hamatum

Paper ID Volume ID Publish Year Pages File Format Full-Text
18256 42715 2007 7 PDF Available
Title
Transformation of steroids by Trichoderma hamatum
Abstract

Trichoderma hamatum KCh25 was used to study the mode of transformation of a series of 3-oxosteroids. This potential has not been previously examined. The strain promoted 1-dehydrogenation, which have been rarely observed in fungi cultures. The metabolism of cortexolone resulted in efficient conversion to 1-dehydrocortexolone, with no other product isolated. The other routes of biotransformations of the substrates included: hydroxylation at equatorial 11α, 6α, and 12β positions, ester bond hydrolysis, oxidation of 17α-hydroxyl group, C-17/C-20 bond scission, and the ring D-lactonization. The correlation between a steroid compound structure and the transformation profile and also succession of the observed reactions has been noticed.

Keywords
Biotransformation; Trichoderma hamatum; 1-Dehydrogenation; Steroid
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 40, Issue 6, 2 May 2007, Pages 1615–1621
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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