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Controlling poly(β-amino ester) network properties through macromer branching

Paper ID Volume ID Publish Year Pages File Format Full-Text
1831 92 2008 11 PDF Available
Title
Controlling poly(β-amino ester) network properties through macromer branching
Abstract

Photopolymerizable and degradable biomaterials are becoming important in the development of advanced materials in the fields of tissue engineering, drug delivery, and microdevices. We have recently developed a library of poly(β-amino ester)s (PBAEs) that form networks with a wide range of mechanical properties and degradation rates that are controlled by simple alterations in the macromer molecular weight or chemical structure. In this study, the influence of macromer branching on network properties was assessed by adding the trifunctional monomer pentaerythritol triacrylate (PETA) during synthesis. This led to a dose-dependent increase in the network compressive modulus, tensile modulus, and glass transition temperature, and a decrease in the network soluble fraction, yet led to only minor variations in degradation profiles and reaction behavior. For instance, the tensile modulus increased from 1.98 ± 0.09 MPa to 3.88 ± 0.20 MPa when the macromer went from a linear structure to a more branched structure with the addition of PETA. When osteoblast-like cells were grown on thin films, there was an increase in cell adhesion and spreading as the amount of PETA incorporated during synthesis increased. Towards tissue engineering applications, porous scaffolds were fabricated by photopolymerizing around a poragen and then subsequently leaching the poragen. Interconnected pores were observed in the scaffolds and observed trends translated to the porous scaffold (i.e., increasing mechanics with increasing branching). These findings demonstrate a simple variation during macromer synthesis that can be used to further tune the physical properties of scaffolds for given applications, particularly for candidates from the PBAE library.

Keywords
Macromer; Biodegradable; Tissue engineering; Branching; Photopolymerization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 2, March 2008, Pages 207–217
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us