fulltext.study @t Gmail

Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
1836 92 2008 9 PDF Available
Title
Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery
Abstract

A novel application of thermally induced phase separation (TIPS) is described enabling the rapid formation of monodisperse porous microspheres. By taking advantage of TIPS processing parameters, the porosity, the pore morphology (bimodal/channel-like/radial towards the centre) and the presence of an open-pore or dense skin region can be tailored. Achievable sizes range from 10 to 2000 μm in diameter. The technique facilitates the homogeneous inclusion of particulate fillers and drugs. Moreover, the combined TIPS/oil-in-water emulsion technique allows for the production of microspheres with isotropic pore morphology with interconnected spherical pores of 30–70 μm and well-formed porous microspheres of 10–200 μm in diameter with an open porous surface. This method is advantageous over existing techniques by avoiding the use of long-term exposure to an aqueous continuous phase as used in oil-in-water or water-in-oil-in-water processing and therefore drug encapsulation efficiencies will be higher.

Keywords
Drug encapsulation; Scaffold; Thermally induced phase separation; Bioactive glass; Antibacterial
First Page Preview
Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 2, March 2008, Pages 264–272
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us