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Immunostimulant activity of an enzymatic protein hydrolysate from green microalga Chlorella vulgaris on undernourished mice

Paper ID Volume ID Publish Year Pages File Format Full-Text
18378 42720 2007 5 PDF Available
Title
Immunostimulant activity of an enzymatic protein hydrolysate from green microalga Chlorella vulgaris on undernourished mice
Abstract

This study examined the effects of oral administration of an enzymatic protein hydrolysate from green microalga Chlorella vulgaris (Cv-PH) on the recovery of both innate and specific immune responses of undernourished Balb/c mice after a 3-day fasting period. Cv-PH was prepared by hydrolysis of ethanol-extracted cell biomass with pancreatin (20 AU/g) at pH 7.5 and 45 °C for 4 h. The treatment with Cv-PH (500 mg/kg) for 8 days provided benefits in terms of haemopoiesis, as judged by the recovery of bone marrow cellularity and the leukocyte counts in peripheral blood, particularly the lymphocyte pool, which increased up to 128% compared to control animals. Starved mice treated with Cv-PH showed a higher number of peritoneal exudate cells and the macrophage activation was demonstrated by the enhancement in glucose consumption and acid phosphatase activities relative to non-supplemented mice. The increased carbon clearance in peripheral blood suggested the stimulation of mononuclear phagocytic system. Cv-PH also stimulated both humoral and cell mediated immune functions positively, such as T-dependent antibody response and the reconstitution of delayed-type hypersensitivity response (DTH). These findings indicate that Chlorella protein hydrolysate can be used for developing physiologically functional foods with immunopotentiating activity.

Keywords
Enzymatic hydrolysis; Protein hydrolysate; Immunostimulant activity; Microalga; Chlorella; Functional foods
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Immunostimulant activity of an enzymatic protein hydrolysate from green microalga Chlorella vulgaris on undernourished mice
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 40, Issue 3, 5 February 2007, Pages 456–460
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us