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Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine

Paper ID Volume ID Publish Year Pages File Format Full-Text
18487 42725 2006 7 PDF Available
Title
Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine
Abstract

Microbial metabolism of evodiamine by Penicillium janthinellum AS 3.510 was investigated. Two metabolites were isolated from the broth and their structures were identified as 10-hydroxyevodiamine and 11-hydroxyevodiamine, by means of their IR, MS and NMR spectral data. Both of the metabolites were proved to be new compounds and showed strong cytotoxic activity in cytotoxicity assay. A major in vivo metabolite of evodiamine was detected in rat urine after oral administration of evodiamine and its structure was proved to be identical with that of the microbial metabolite 10-hydroxyevodiamine by HPLC–MS/MS analysis and comparison with the reference standard. The time course of microbial transformation of evodiamine and its urinary excretion in rat was proposed.

Keywords
Evodiamine; Metabolite; Biotransformation; Hydroxylation
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Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 39, Issue 4, 2 August 2006, Pages 561–567
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
You save - $31
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