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Designing porosity and topography of poly(1,3-trimethylene carbonate) scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
1857 93 2009 14 PDF Available
Title
Designing porosity and topography of poly(1,3-trimethylene carbonate) scaffolds
Abstract

Using phase separation micromolding (PSμM) we developed porous micro-patterned sheets from amorphous poly(1,3-trimethylene carbonate) (PTMC). The use of these PTMC sheets can be advantageous in tissue engineering applications requiring highly flexible constructs. Addition of poly(ethylene oxide) (PEO) in various amounts to PTMC casting solutions provides PTMC sheets with tailored porosity and pore sizes in the range 2–20 μm. The pore-forming effect of PEO during the phase separation process is evaluated and glucose transport measurements show that the pores are highly interconnected. Additionally, tailoring the micro-pattern design yields PTMC sheets with various surface topographies. Cell culturing experiments with C2C12 pre-myoblasts revealed that cell attachment and proliferation on these sheets is relatively high and that the micro-pattern topography induces a clearly defined cell organization.

Keywords
Tissue engineering scaffold; Phase separation; Micro-patterning; Poly(trimethylene carbonate); Cell attachment and proliferation
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Designing porosity and topography of poly(1,3-trimethylene carbonate) scaffolds
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 9, November 2009, Pages 3281–3294
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us