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Hydrolysis of nitriles and amides by filamentous fungi

Paper ID Volume ID Publish Year Pages File Format Full-Text
18588 42726 2006 5 PDF Available
Title
Hydrolysis of nitriles and amides by filamentous fungi
Abstract

Screening of culture collection afforded nitrile-utilizing fungi belonging to genera Aspergillus, Talaromyces and Penicillium. Fusarium solani O1 was enriched from soil using 3-cyanopyridine as the sole source of nitrogen. This strain, and Penicillium multicolor CCF 2244 (the best one of the culture collection strains), showed comparable specific benzonitrile-hydrolyzing activities (0.95 and 0.87 μmol of benzoic acid h−1 mg−1 of dry cell weight at 28 °C, respectively). These fungi showed similar substrate specificities for substituted benzonitriles and heterocyclic nitriles but different pH and temperature optima (pH 8 and 38 °C for P. multicolor, pH 7 and 48 °C for F. solani). Amides as by-products were produced from some heterocyclic nitriles. Both fungi showed an amidase activity for nicotinamide.

Keywords
Biotransformation; Fusarium solani; Penicillium multicolor; Nitrilase; Nitrile; Amidase; Amide
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Hydrolysis of nitriles and amides by filamentous fungi
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 38, Issues 1–2, 3 January 2006, Pages 260–264
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us