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The influences of aerobic-dark and anaerobic-light cultivation on CoQ10 production by Rhodobacter sphaeroides in the submerged fermenter

Paper ID Volume ID Publish Year Pages File Format Full-Text
18641 42731 2007 5 PDF Available
Title
The influences of aerobic-dark and anaerobic-light cultivation on CoQ10 production by Rhodobacter sphaeroides in the submerged fermenter
Abstract

Ubiquinone-10 (CoQ10) production was performed in a submerged fermenter through the culture of a facultative bacterium-Rhodobacter sphaeroides. Effects of the aerobic-dark cultivation under different dissolved oxygen (DO) levels and the anaerobic-light cultivation of R. sphaeroides on CoQ10 production were investigated. In the aerobic-dark cultivation, four levels of dissolved oxygen at 60 ± 5%, 30 ± 5%, 10 ± 5% and 0% controlled by the agitation adjustment were performed. The results showed that the anaerobic-light cultivation had a higher CoQ10 concentration of 18.2 g/L over all the aerobic-dark batches. Among the batches of aerobic-dark cultivation, the maximum CoQ10 concentration of 10.5 mg/L was observed in the cultivation at 0% dissolved oxygen. The anaerobic-light cultivation (18.2 g/L) had more than 70% increased of CoQ10 concentration as compared to the maximum CoQ10 concentration obtained from the aerobic-dark cultivation at 0% DO (10.5 g/L). However, a much longer lag phase in the anaerobic-light batch led to a lower overall CoQ10 production rate (0.095 mg/L/h) as compared to the value of 0.146 mg/L/h in the batch of aerobic-dark at 0% DO. Except for the long fermentation period, the high energy consumption required from the light irradiation in the anaerobic-light batch led the anaerobic-light cultivation for CoQ10 production economically uncompetitive. Therefore, the cultivation of R. sphaeroides under the situation of aerobic-dark at 0% DO was suggested to be applied in the scale-up CoQ10 production.

Keywords
CoQ10; Rhodobacter; Submerged culture; Dissolved oxygen
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The influences of aerobic-dark and anaerobic-light cultivation on CoQ10 production by Rhodobacter sphaeroides in the submerged fermenter
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 41, Issue 5, 1 October 2007, Pages 600–604
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us