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Reduction of carbon–carbon double bonds using Acetobacterium woodii: Determination of the optimum inducer structure

Paper ID Volume ID Publish Year Pages File Format Full-Text
18666 42732 2006 6 PDF Available
Title
Reduction of carbon–carbon double bonds using Acetobacterium woodii: Determination of the optimum inducer structure
Abstract

Various cinnamate derivatives were tested as inducers for reduction of C–C double bonds in Acetobacterium woodii. The double bond and a phenyl ring were essential for induction, since crotonate and hydrocaffeate were ineffective as inducers whereas cinnamate derivatives were effective. Induction was improved by ring hydroxylation, except in the 2-position, since caffeate and 3- and 4-hydroxy cinnamate were the most effective inducers. The carboxylate group of cinnamate could be replaced by ester (methylcinnamate) or aldehyde (cinnamaldehyde), but not by alcohol (cinnamyl alcohol) or methyl (trans-β-methylstyrene). Effective inducers were hydrogenated efficiently during growth, whereas ineffective inducers were not metabolised. Several inducers with intermediate effectiveness were hydrogenated in low yield with accompanying metabolism of other functional groups. Overall, caffeate (3,4-dihydroxycinnamate) was the best inducer.

Keywords
Biocatalytic hydrogenation; C–C double bond reduction; Inducer structure; Acetobacterium woodii; Biocatalysis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 39, Issue 5, 4 September 2006, Pages 1066–1071
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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