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A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studies

Paper ID Volume ID Publish Year Pages File Format Full-Text
1869 93 2009 12 PDF Available
Title
A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studies
Abstract

Composite films of poly(lactic-co-glycolic-acid) with multi-walled carbon nanotubes (PLGA–MWCNT) having two different nanotube orientations, namely random and vertically aligned, have been fabricated and characterized. The effect of these nanostructured surfaces on platelet adhesion is evaluated. In particular, the thrombogenicity of the nanostructured composite films is compared with that of pristine graphite (a low thrombogenic material) and PLGA film, in order to determine the influence of surface chemistry and topography on platelet adhesion. The results in this study show that the PLGA–MWCNT composite with vertically aligned nanotubes exhibits very low levels of fibrinogen adsorption and platelet adhesion, which can be attributed to both chemical and topographical effects. Platelet adhesion shows a good correlation with the presence of COOH groups and appears to be sensitive to the topographic features of the composite films. The results in this study suggest that in addition to chemistry, nanotopographical surface modifications could be an effective strategy in the development of low thrombogenic and hemocompatible materials.

Keywords
Anti-thrombotic materials; Platelet adhesion; Nanotopography; Carbon nanotube composites; Poly (lactide-co-glycolic-acid)
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A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studies
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 9, November 2009, Pages 3411–3422
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us