fulltext.study @t Gmail

Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
1872 93 2009 12 PDF Available
Title
Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds
Abstract

Guar gum (GG) is a non-ionic polysaccharide that is found abundantly in nature and has many properties desirable for biomedical applications. In the present work GG with molecular weights ranging from 74 to 210 kDa was modified with glycidyl methacrylate (GMA) to produce a series of water-soluble photopolymerizable guar gum–methacrylate (GG–MA) macromonomers of different molecular weights. We investigated the effects of molecular weight of GG–MA macromonomers from 102 to 216 kDa and with percent degree of methacrylation (%DM) ranging from 14% to 56% on the properties of GG–MA hydrogels. GG–MA hydrogels exhibited a three-dimensional open cell microstructure with an average pore size ranging from ∼10 to 55 μm and an average pore density of from ∼2.4 × 106 to 8.6 × 107 pores cm−3. The hydrogels exhibited equilibrium swelling ratios ranging from ∼22% to 63%. The degree of in vitro enzymatic biodegradation of the hydrogels decreased linearly with increasing gel content and the degree of methacrylation of the respective macromonomers. The human endothelial cell line EA.hy926 was photo-encapsulated in the GG–MA hydrogels. Cells remained viable at low macromonomer concentrations, but cell viability decreased sequentially as the macromonomer concentration increased. GG–MA hydrogels with a 0.05 wt.% GG–MA macromonomer concentration revealed excellent endothelial cell proliferation, similar to that of the Matrigel™ control.

Keywords
Guar gum–methacrylate; Photopolymerizable macromonomer; Biodegradable hydrogels; Cytocompatibility; Tissue engineering scaffold
First Page Preview
Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 9, November 2009, Pages 3441–3452
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us