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Improvement the tolerance of baker's yeast to toxic substrate/product with cloud point system during the whole cell microbial transformation

Paper ID Volume ID Publish Year Pages File Format Full-Text
18724 42738 2007 6 PDF Available
Title
Improvement the tolerance of baker's yeast to toxic substrate/product with cloud point system during the whole cell microbial transformation
Abstract

The industrial process of a whole-cell microbial transformation is usually hindered by the toxicity or inhibition of a high substrate/product concentration. Especially in a biocatalytic redox process, the cofactor regeneration with the viable cells is a key of the whole cell microbial transformation. In present work, growing culture of Saccharomyces cerevisiae (baker's yeast) in a nonionic surfactant mediated cloud point system was carried out. Then the tolerances of baker's yeast cells against a high substrate/product concentration and a long term of biocatalytic reduction of acetophenone to produce 1-phenylethanol as a model were examined in the cloud point system. The long term of cofactor regeneration at a high substrate concentration in the cloud point system make the cloud point system potential for further development as a novel two-phase partitioning system for production of chiral compounds by microbial transformation.

Keywords
Cloud point system; Substrate/product inhibition; Whole cell biotransformation; Cofactor regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 41, Issue 3, 2 August 2007, Pages 296–301
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us