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A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a

Paper ID Volume ID Publish Year Pages File Format Full-Text
18729 42738 2007 4 PDF Available
Title
A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
Abstract

A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate by nine microorganisms in various culturing conditions including the inoculum density, pH of the medium, amounts of the precursor and surfactant or oil containing medium was presented. The microorganisms used were Cunninghamella blakesleeana ATCC 8688a, C. blakesleeana ATCC 8688b, Curvularia lunata ATCC 12017, Aspergillus niger TISTR 3245, Curvularia sp. TISTR 3289, Curvularia sp. TISTR 3291, Cunninghamella echinulata F 1307943, C. lunata F 14894 and Penicillium sp. F 879414. C. blakesleeana ATCC 8688a gave the highest yield of 85.6 ± 6.2% at the initial cell number of 1 × 103 CFU, pH 6.5 and incubated for 24 h. The result from this study can not only be applied for the chemical synthesis processes which involve the hydroxylation reaction, but also an attractive approach for industrial production because of lower cost, less time consuming and more environmental friendly.

Keywords
Cunninghamella blakesleeana ATCC 8688a; Cortexolone-21-acetate; Hydrocortisone acetate; One-step biotransformation
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A novel one-step biotransformation of cortexolone-21-acetate to hydrocortisone acetate using Cunninghamella blakesleeana ATCC 8688a
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 41, Issue 3, 2 August 2007, Pages 322–325
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us