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Immobilization of Rhodococcus sp. AJ270 in alginate capsules and its application in enantioselective biotransformation of trans-2-methyl-3-phenyl-oxiranecarbonitrile and amide

Paper ID Volume ID Publish Year Pages File Format Full-Text
18742 42741 2006 5 PDF Available
Title
Immobilization of Rhodococcus sp. AJ270 in alginate capsules and its application in enantioselective biotransformation of trans-2-methyl-3-phenyl-oxiranecarbonitrile and amide
Abstract

Rhodococcus sp. AJ270, a nitrile hydratase/amidase-containing microorganism, were immobilized in alginate capsules. The influences of the bead size and the crosslinking agent on morphology and the biocatalytic activity of the cells were examined. In the presence of an organic co-solvent, such as methanol or acetone (5%), the encapsulated Rhodococcus sp. AJ270 has been found to catalyze efficiently the biotransformation of racemic trans-2-methyl-3-phenyl-oxiranecarbonitrile and its amide to yield highly enantiopure 2R,3S-(−)-2-methyl-3-phenyl-oxiranecarboxamide in at least seven runs.

Keywords
Encapsulation; Rhodococcus sp. AJ270; Enantioselective biotransformation; Nitrile hydratase; Amidase
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Immobilization of Rhodococcus sp. AJ270 in alginate capsules and its application in enantioselective biotransformation of trans-2-methyl-3-phenyl-oxiranecarbonitrile and amide
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 39, Issue 1, 1 June 2006, Pages 1–5
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us