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Bioconversion of methyl protodioscin by Penicillium melinii cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
18781 42743 2006 7 PDF Available
Title
Bioconversion of methyl protodioscin by Penicillium melinii cells
Abstract

Bioconversion of methyl protodioscin (1) by Penicillium melinii was investigated. Seven bioconversion products were isolated and identified. Three of them were glycosidation products and were new compounds. Their structures were identified to be 3-O-[α-l-rhamnopyranosyl-(1 → 2)-{α-l-rhamnopyranosyl-(1 → 4)}-β-d-glucopyranosyl]-26-O-[β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl]-25(R)-furost-5,20(22)-diene-3β,26-triol (2), 3-O-[α-l-rhamnopyranosyl-(1 → 2)-{α-l-rhamnopyranosyl-(1 → 4)}-β-d-glucopyranosyl]-26-O-[β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl]-25(R)-furost-5-ene-3β,26-triol (3), 16β-[4′-methyl-5′-O-(β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl)-pentanoxyl]-pregn-5-en-3β-ol-20-one-O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 4)]-β-d-glucopyranoside (4), respectively. To the best knowledge we known, this was the first time to find the type of furostanol saponins that had disugar at C-26. The proposed biosynthetic pathways of methyl protodioscin were drawn. Most bioconversion products showed considerable cytotoxic activities against HepG2, NCI-H460, MCF-7 and HeLa cell lines compared to methyl protodioscin.

Keywords
Methyl protodioscin; Microbial conversion; Glucose-conjugation; Anticancer activities
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Publisher
Database: Elsevier - ScienceDirect
Journal: Enzyme and Microbial Technology - Volume 38, Issues 3–4, 1 February 2006, Pages 400–406
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us