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Characterization, physicochemical properties and biocompatibility of La-incorporated apatites

Paper ID Volume ID Publish Year Pages File Format Full-Text
1879 93 2009 12 PDF Available
Title
Characterization, physicochemical properties and biocompatibility of La-incorporated apatites
Abstract

In this study, the physicochemical properties and biocompatibilities of La-containing apatites were intensively investigated together with their characterizations in terms of composition, structure, valent state and morphology using X-ray diffraction, Fourier-transform infrared spectra, X-ray photoelectron spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy, respectively. The results indicate that the La3+ ion can be incorporated into the crystal lattice of hydroxyapatite resulting in the production of La-incorporated apatites (LaxCa10−x(PO4)6(OH)2+x−2yOy□y−x (x ⩽ 0.5, y < 1 + x/2) or LaxCa10−x(PO4)6Oy□y−x (0.5 < x < 2, y = 1 + x/2)) by high-temperature solid phase synthesis. For La content <20%, the product is composed of the major phase, Lax-OAP, as well as a small amount of tricalcium phosphate, but for a La content of 20%, the product is pure La-incorporated oxyapatite with the formula La2Ca8(PO4)6O2 (La2-OAP, x = 2, y = 2). It is also found that the La content plays important roles in both the physicochemical properties and biocompatibilities of the La-incorporated apatites. In contrast to La-free apatite, La-incorporated apatites possess a series of attractive properties, including higher thermal stability, higher flexural strength, lower dissolution rate, larger alkaline phosphatase activity, preferable osteoblast morphology and comparable cytotoxicity. In particular, the sintered La-incorporated apatite block achieves a maximal flexure strength of 66.69 ± 0.98 MPa at 5% La content (confidence coefficient 0.95), increased 320% in comparison with the La-free apatite. The present study suggests that the La-incorporated apatite possesses application potential in developing a new type of bioactive coating material for metal implants and also as a promising La carrier for further exploring the beneficial functions of La in the human body.

Keywords
La-containing apatite; Flexural strength; Degradability; Thermal stability; Biocompatibility
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Characterization, physicochemical properties and biocompatibility of La-incorporated apatites
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 9, November 2009, Pages 3512–3523
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us