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Formation of hollow solid lipid micro- and nanoparticles using supercritical carbon dioxide

Paper ID Volume ID Publish Year Pages File Format Full-Text
18866 43036 2016 10 PDF Available
Title
Formation of hollow solid lipid micro- and nanoparticles using supercritical carbon dioxide
Abstract

•A simple hollow solid lipid micro/nanosphere formation method is reported.•Melting point of FHSO decreased from 68.5 °C to 57 °C above 120 bar in CO2.•Particles exhibited broadened melting range and decreased melting point.•Decreasing the nozzle diameter changed the polymorphism of the particles from β to α.

Hollow solid lipid micro- and nanoparticles were formed from fully hydrogenated soybean oil (FHSO) using atomization of the carbon dioxide (CO2)-expanded lipid. Melting point of FHSO decreased from 68.5 °C to 57 °C (0.096 °C/bar) above 120 bar in pressurized CO2. Processing conditions of 50 μm nozzle diameter and 200 bar CO2 pressure yielded smaller (d50% = 278 nm) hollow solid lipid particles. Increasing nozzle diameter and pressure affected the particle morphology and size negatively. Shell thickness of the particles decreased with increasing pressure at the same nozzle diameter. Decreasing the nozzle diameter yielded the polymorphism of the particles from β to α. Melting point of the particles shifted to a lower melting range and broadened the melting range compared to FHSO. The results showed that the reported supercritical CO2-assisted atomization process is a promising method to form hollow solid lipid micro- and nanoparticles to develop bioactive delivery systems.

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Keywords
FHSO, fully hydrogenated soybean oil; SC-CO2, supercritical carbon dioxide; SEM, scanning electron microscopy; DSC, differential scanning calorimetry; XRD, X-ray powder diffractionNanoparticle; Supercritical carbon dioxide; Lipid; Melting; Oil
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Publisher
Database: Elsevier - ScienceDirect
Journal: Food and Bioproducts Processing - Volume 98, April 2016, Pages 151–160
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us