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Lovastatin production by Aspergillus terreus using lignocellulose biomass in large scale packed bed reactor

Paper ID Volume ID Publish Year Pages File Format Full-Text
18978 43038 2014 9 PDF Available
Title
Lovastatin production by Aspergillus terreus using lignocellulose biomass in large scale packed bed reactor
Abstract

•Lovastatin production 2.74 mg g−1 dry substrate in 7 L and 2.13 mg g−1 in 1200 L SSF bioreactor.•Mass transfer and reaction limitations on bioconversion in the 1200 L reactor was studied.•Variations in temperature, CO2 evolution and Damköhler number observed.•1.86 mg g−1 dry substrate of lovastatin at the operating condition of 0.19 vvm airflow rate and 54% substrate composition (wC) after day 5.

The effect of superficial air velocity on lovastatin production by Aspergillus terreus PL10 using wheat bran and wheat straw was investigated in a 7 L and a 1200 L packed bed reactor. Mass transfer and reaction limitations on bioconversion in the 1200 L reactor was studied based on a central composite design of experiments constructed using the superficial air velocity and solid substrate composition as variables and lovastatin production as response. The surface response prediction showed a maximum lovastatin production of 1.86 mg g−1 dry substrate on day 5 of the bioconversion process when the reactor was operated using 0.19 vvm airflow rate (23.37 cm min−1 superficial air velocity) and 54% substrate composition (wC). Lovastatin production did not increase significantly with superficial air velocity in the 7 L reactor. Variation in temperature and exit CO2 composition was recorded, and the Damköhler number was calculated for lovastatin production at these two scales. The results showed that in larger reactors mass transfer limitation controlled bioconversion while in smaller reactors bioconversion was controlled by reaction rate limitations. In addition, mass transfer limitations in larger reactors reduced the rate of metabolic heat removal, resulting in hot spots within the substrate bed.

Keywords
Superficial air velocity; Solid-state bioconversion; Lovastatin production; Packed bed bioreactor; Damköhler number; Aspergillus terreus
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Publisher
Database: Elsevier - ScienceDirect
Journal: Food and Bioproducts Processing - Volume 92, Issue 4, October 2014, Pages 416–424
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us