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Theoretical risk assessment of magnesium alloys as degradable biomedical implants ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
1908 94 2010 5 PDF Available
Title
Theoretical risk assessment of magnesium alloys as degradable biomedical implants ☆
Abstract

The theoretical tolerable implant masses for ten magnesium alloys as degradable biomedical implant materials are evaluated in this study. Dose–response assessment is conducted using toxicological data from authoritative public health agencies such as the US Agency for Toxic Substances and Disease Registry and the USEPA Integrated Risk Information System, and assuming 1 year of even corrosion. Uncertainty factors adopted by the agencies are used. The tolerable limits corresponding to various component elements in an alloy are considered separately, and the lowest tolerable limit is selected as the tolerable limit of the alloy. The results show that aluminum is usually the component element with the lowest tolerance, and the tolerable mass for Al-containing magnesium alloys fall to around or below 1 g per person per year, while the limit for other magnesium alloys can well exceed 10 g. Deficits in the toxicological data of some component elements are noted. This study illustrates that toxicological calculations should be taken into consideration when developing novel degradable metallic implants.

Keywords
Aluminum; Toxicology; Risk assessment; Metallic implant; Degradable
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Theoretical risk assessment of magnesium alloys as degradable biomedical implants ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 5, May 2010, Pages 1808–1812
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us