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On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg–Y–Zn alloys ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
1910 94 2010 10 PDF Available
Title
On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg–Y–Zn alloys ☆
Abstract

A design strategy deployed in developing new biodegradable Mg–Y–Zn alloys is summarized and the key factors influencing their suitability for medical applications are described. The Mg–Y–Zn alloys reveal microstructural features and mechanical characteristics expected to be appropriate for vascular intervention applications. The focus of this article lies in the evaluation of the degradation performance and biological response of the alloys with respect to their potential as implant materials (stents). The degradation characteristics analyzed by immersion testing and electrochemical impedance spectroscopy in simulated physiological media reveal slow and homogeneous degradation. In vitro cell tests using human umbilical vein endothelial cells indicate good cytocompatibility on the basis of the alloys’ eluates (extracts). Animal studies carried out with pigs on Mg–2Y–1Zn (in wt.%) reveal an auspicious in vivo performance. Evaluation of preparations derived from implants in various types of tissues indicates homogeneous degradation and only limited gas formation during in vivo testing. The characteristics of the tissue reactions indicate good biocompatibility. The new Mg–Y–Zn alloys show an interesting combination of preferred microstructural, mechanical, electrochemical and biological properties, which make them very promising for degradable implant applications.

Keywords
Degradable metals; Magnesium; Bio-corrosion; Biocompatibility; In vitro and in vivo studies
First Page Preview
On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg–Y–Zn alloys ☆
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 5, May 2010, Pages 1824–1833
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering