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Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
1911 94 2010 9 PDF Available
Title
Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines ☆
Abstract

Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REEs) are used to improve the mechanical properties of the alloys, but in more or less undefined mixtures. For some elements of this group, data on toxicity and influence on cells are sparse. Therefore in this study the in vitro cytotoxicity of the elements yttrium (Y), neodymium (Nd), dysprosium (Dy), praseodymium (Pr), gadolinium (Gd), lanthanum (La), cerium (Ce), europium (Eu), lithium (Li) and zirconium (Zr) was evaluated by incubation with the chlorides (10–2000 μM); magnesium (Mg) and calcium (Ca) were tested at higher concentrations (200 and 50 mM, respectively). The influence on viability of human osteosarcoma cell line MG63, human umbilical cord perivascular (HUCPV) cells and mouse macrophages (RAW 264.7) was determined, as well as the induction of apoptosis and the expression of inflammatory factors (TNF-α, IL-1α). Significant differences between the applied cells could be observed. RAW exhibited the highest and HUCPV the lowest sensitivity. La and Ce showed the highest cytotoxicity of the analysed elements. Of the elements with high solubility in magnesium alloys, Gd and Dy seem to be more suitable than Y. The focus of magnesium alloy development for biomedical applications should include most defined alloy compositions with well-known tissue-specific and systemic effects.

Keywords
Magnesium; Rare earth elements; In vitro; Toxicity; Inflammatory response
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Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 5, May 2010, Pages 1834–1842
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us