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A novel nanocomposite polymer for development of synthetic heart valve leaflets

Paper ID Volume ID Publish Year Pages File Format Full-Text
1922 95 2009 9 PDF Available
Title
A novel nanocomposite polymer for development of synthetic heart valve leaflets
Abstract

A novel nanocomposite polymer with a polycarbonate soft segment (PCU) and polyhedral oligomeric silsesquioxanes (POSS) nanoparticle (POSS–PCU) has been selected for a synthetic heart valve due to its superior biocompatibility and in vivo biostability. However, the development of synthetic heart valves from polymeric materials requires an understanding of the basic mechanical and surface properties of the polymer. In this study, the mechanical properties of POSS–PCU, including tensile strength, tear strength and hardness, were tested and compared to control (PCU). The surface property was analyzed using contact angle measurement and the resistance to platelet adhesion was also investigated. POSS–PCU (hardness 84 ± 0.8 Shore A) demonstrated significantly higher tensile strength 53.6 ± 3.4 and 55.9 ± 3.9 N mm−2 at 25 and 37 °C, respectively) than PCU (33.8 ± 2.1 and 28.8 ± 3.4 N mm−2 at 25 and 37 °C, respectively). Tensile strength and elongation at break of POSS–PCU was significantly higher than PCU at both 25 and 37 °C (P < 0.001). POSS–PCU showed a relatively low Young’s modulus (25.9 ± 1.9 and 26.2 ± 2.0 N mm−2) which was significantly greater in comparison with control PCU (9.1 ± 0.9 and 8.4 ± 0.5 N mm−2) at 25 and 37 °C, respectively, with 100 μm thickness. There was no significant difference (P > 0.05) in tear strength between POSS–PCU and PCU at 25 °C. However, tear strength increased significantly (P < 0.001) (at 37 °C) as the thickness increased from 100 μm (51.0 ± 3.3 N mm−1) to 200 μm (63 ± 1.5 N mm−1). The surface of POSS–PCU was significantly less hydrophilic than that of PCU.

Keywords
Polyurethane; Platelet adhesion; Mechanical property; Synthetic heart valve
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A novel nanocomposite polymer for development of synthetic heart valve leaflets
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 7, September 2009, Pages 2409–2417
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us